Target Urinary Analytes for the Gas Chromatographic-Mass Spectrometric Detection of Procyclidine and Benzhexol in Drug Abuse Cases

Gas-chromatographic Mass-spectrometric Detection

Cystathionine has been reported to undergo enzymatic changes leading to the formation of seven membered cyclic products (Ricci, G., Santoro, L., Achilli, M., Matarese, R. M., Nardini, M., and Cavallini, D. (1983) J. Biol. Chem. 258, 10511-10517; Cavallini, D., Costa, M., Pensa, B., and Coccia, R. (1985) Biochem. Int. 10, 641-646). Gas-chromatographic and mass-spectrometric evidence reported in...

Gas chromatographic - mass spectrometric methods for the detection and identification of anabolic steroid drugs.

*Permission to carry out these drug studies was granted by the Northwick Park Hospital Ethical Committee. steroids. The columns were washed with water and the steroids recovered by elution with ethanol. The ethanol was taken to dryness and the residue dissolved in 0.5M acetate buffer (pH 4.6) and the steroid conjugates were hydrolysed by two enzymes present in snail digestive juice (Helix pomat...

Assays for chloramphenicol compared: radioenzymatic, gas chromatographic with electron capture, and gas chromatographic-mass spectrometric.

We compared these three techniques for measuring chloramphenicol in serum or urine. Although each has its particular advantages, any of them is shown to be satisfactory and may appropriately be used by clinical laboratories, according to the facilities available.

Alternative Sample Preparation Techniques in Gas Chromatographic - Mass Spectrometric Analysis of Urinary Androgenic Steroids

Gas-chromatographic/mass-spectrometric determination of theophylline in whole blood.

We describe a combined gas-chromatographic mass-spectrometric method for determination of theophylline in whole blood. With use of a probability-based matching approach, the extensive gas-chromatographic interference did not affect mass-spectrometric quantitation of theophylline. Concentrations expected and found were linearly related from 1 to 60 mg/liter; the run-to-run coefficient of variati...